Whereas very low-depend MBL hardly ever progresses to CLL, large-depend MBL progresses to CLL demanding therapy in a rate of one% to 2% every year. Significant-count MBL is distinguished from Rai 0 CLL determined by if the B-cell depend is previously mentioned or underneath 5 × 109/L. Though folks with the two higher-count MBL and CLL Rai phase 0